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Description

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Trial dose range: 112mg, once weekly, subcutaneous Standard escalation: 2mg +2mg every 4 weeks 12mg (~20 weeks) Pharmacokinetics: half-life ~6 days

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semaglutide 1.0 mg showing greater HbA1c reduction (2.5% vs 1.9%) and weight loss (11.2 kg vs 6.7 kg) [2] SURPASS-3: Combination with metformin

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Inform the treating clinician of the substance used

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